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	<title>Pollogen Blog &#187; free radicals</title>
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		<title>Popular Dermal Fillers</title>
		<link>http://www.pollogen.com/blog/2010/03/10/popular-dermal-fillers/</link>
		<comments>http://www.pollogen.com/blog/2010/03/10/popular-dermal-fillers/#comments</comments>
		<pubDate>Wed, 10 Mar 2010 07:45:47 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Pollogen - TriPollar RF Technology]]></category>
		<category><![CDATA[Tripollar]]></category>
		<category><![CDATA[aging]]></category>
		<category><![CDATA[aging skin]]></category>
		<category><![CDATA[alternative]]></category>
		<category><![CDATA[anti-aging]]></category>
		<category><![CDATA[anti-wrinkle]]></category>
		<category><![CDATA[antiaging]]></category>
		<category><![CDATA[botox]]></category>
		<category><![CDATA[collagen]]></category>
		<category><![CDATA[deep wrinkles]]></category>
		<category><![CDATA[derma fillers]]></category>
		<category><![CDATA[dermal fillers]]></category>
		<category><![CDATA[Epidermis]]></category>
		<category><![CDATA[extreme]]></category>
		<category><![CDATA[extreme change]]></category>
		<category><![CDATA[face lift]]></category>
		<category><![CDATA[free radicals]]></category>
		<category><![CDATA[invasive]]></category>
		<category><![CDATA[natural]]></category>
		<category><![CDATA[natural look]]></category>
		<category><![CDATA[natural process]]></category>
		<category><![CDATA[painless]]></category>
		<category><![CDATA[proportion]]></category>
		<category><![CDATA[proportions]]></category>
		<category><![CDATA[recovery time]]></category>
		<category><![CDATA[side effects]]></category>
		<category><![CDATA[skin]]></category>
		<category><![CDATA[skin rejuvenation]]></category>
		<category><![CDATA[skin tightening]]></category>
		<category><![CDATA[superficial wrinkles]]></category>
		<category><![CDATA[wrinkle]]></category>
		<category><![CDATA[wrinkles]]></category>
		<category><![CDATA[Wrinkles on the face]]></category>

		<guid isPermaLink="false">http://www.pollogen.com/blog/?p=98</guid>
		<description><![CDATA[Aging is a natural process that all women and men who live to a ripe mature age will experience. Even though aging is also associated with wisdom and experience, it is not easy to convince oneself that the wrinkles and sagging skin are actually a wonderful sign of the wisdom acquired through life experience. In [...]]]></description>
			<content:encoded><![CDATA[<p>Aging is a natural process that all women and men who live to a ripe mature age will experience. Even though aging is also associated with wisdom and experience, it is not easy to convince oneself that the wrinkles and sagging skin are actually a wonderful sign of the wisdom acquired through life experience. In the past the only treatment option for aging skin and body involved invasive surgery that often results in an extreme change of facial expression and proportions and requires substantial recovery time.<br />
The aesthetic industry has evolved in the past years offering many viable alternatives to the knife. Dermal fillers have become a common treatment for aging skin, and wrinkles. Contrary to face lift results which induce tight, flattened pulled skin, derma fillers, when injected correctly, will result in a natural fuller look  (When done poorly the outcome can include lumps and granules or even out of proportion facial contour).<span id="more-98"></span><br />
Derma fillers are minimally invasive treatments and most can be performed during a lunch break with minimal recovery time. Common side effects include bruising, swelling, pain and at times, allergic reaction. Results are temporary, lasting 6-18 months, depends on the filler and the individual being treated.<br />
It is very important to carefully select the treating physician, a good question to ask a physician would be how many times he has performed a certain procedure with a certain dermal filler, make sure he is very familiar with it  (Not sure what to suggest as an acceptance number in the answer to this question. I personally would probably feel better with an answer of above 50 times).<br />
There are different types of dermal fillers out there, some are synthetic some natural.<br />
Early dermal fillers were of synthetic origin (silicon) or natural source (bovine- cow) collagen and fat.<br />
Bovine (cow) collagen was the first approved dermal filler in the United States in the early 1980’s.  The leading brand of bovine collagen were Zyderm ® and Zyplast.<br />
It was considered the gold standard and all other dermal implants were measured compared to its effectiveness. Results can last 3-18 months, although many recipients report that a repeat treatment is usually required at 3-5 months.<br />
Human collagen was introduced to the aesthetic market in the late 1990. The leading brand was Cosmoderm and Cosmoplast (manufactured by the same company). Cosmoderm is used for treatment of superficial wrinkles, Cosmoplast for deeper wrinkles.<br />
Natural hyaluronic acid  is a very popular derma filler due to the low allergy rate and the good results it provides (Restylane, Perlane, Juvederm and Prevelle Silk). Hyaluronic acid is a naturally accruing component in the skin and composes a large percentage of the extracellular matrix. Hyaluronic acid in the epithel is linked with collagen production and increased skin hydration, enabling fuller smoother looking skin. In 2003 the FDA approved the use of hyaluronic acid (Restylane) as derma filler for the temporary treatment of wrinkles.<br />
There are quite a few available dermal filler brands available, listed below are a few popular brands with explanations about their way of action, and advantages.<br />
Restylane – Produced in Sweden, the first hyaluronic acid filler made of non animal source. It is used around the eyes, lips and nasolabial area (folds around the nose and mouth). It is claimed to last 6 months but there are reported incidents extended durations of the  treatment effect (up to18 months).<br />
Perlane – Manufactured by same company that produces Restylane in Sweden. Consists of hyaluronic acid but larger molecules than Restylane, therefore is more suitable for deeper wrinkles. It also seems to have a longer efficacy period even though the FDA has approved it as a dermal filler for 6 months.<br />
Radiesse – Contains calcium hydroxylapatite which are small calcium spheres in a gel base. The injection of the filler actually serves to “plump” the injected area and also induce generation of new collagen that is layered on the sphere structures. The allergy rate to this filler is very low and the manufacture claims that the small calcium spheres  and the gel will actually disintegrate but the newly generated collagen will be significant enough to sustain the treatment effects. Radiesse is also suitable for treatment of HIV patients suffering from facial lipoatrophy (diminishing of facial fat), a condition induced by HIV treatment drugs.<br />
Evolence – Made of Porcine collagen (pork) which is very similar to human collagen therefore it is a good dermal filler as allergy rate to it are very low, in addition the side effects are minor.<br />
Prevelle silk – Hyaluronic acid combined with Lidocane (a local anasthsia agent). Combining the filler with lidocane enables treatment of sensitive areas (like the lips) with very little discomfort.<br />
Juvederm – Hyaluronic acid filler manufactured by allergen (same company that produces Botox). It is especially suitable for larger filler “jobs” and correction of irregularities and deep wrinkles.<br />
Some customers prefer combination of various treatments for targeting the aging skin and body. If you are looking into combining dermal fillers with other skin tightening methods make sure to enable about a month or even longer (follow the manufacture’s specific instructions) to enable the filler to complete its course of action before indulging in other anti ageing treatments.</p>
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		<slash:comments>33</slash:comments>
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		<title>What are Free Radicals and Oxidative Stress and can Antioxidants help?</title>
		<link>http://www.pollogen.com/blog/2009/12/01/what-are-free-radicals-and-oxidative-stress-and-can-antioxidants-help/</link>
		<comments>http://www.pollogen.com/blog/2009/12/01/what-are-free-radicals-and-oxidative-stress-and-can-antioxidants-help/#comments</comments>
		<pubDate>Tue, 01 Dec 2009 07:12:08 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Tripollar]]></category>
		<category><![CDATA[anti-aging]]></category>
		<category><![CDATA[cell]]></category>
		<category><![CDATA[collagen regeneration]]></category>
		<category><![CDATA[free radicals]]></category>
		<category><![CDATA[metabolism]]></category>
		<category><![CDATA[Reactive Oxygen Species]]></category>
		<category><![CDATA[skin]]></category>

		<guid isPermaLink="false">http://www.pollogen.com/blog/?p=79</guid>
		<description><![CDATA[ The definition of free radicals according to Webster’s new College Dictionary:
“An atom or molecule having at least one unpaired electron: free radicals are usually very reactive and unstable, and can damage healthy body cells “.
One group of free radicals which is a byproduct of mitochondrial oxygen metabolism processes is Reactive Oxygen Species (ROS).  The ROS [...]]]></description>
			<content:encoded><![CDATA[<p> The definition of free radicals according to Webster’s new College Dictionary:</p>
<p><strong>“</strong>An atom or molecule having at least one unpaired electron: free radicals are usually very reactive and unstable, and can damage healthy body cells “.<span id="more-79"></span></p>
<p>One group of free radicals which is a byproduct of mitochondrial oxygen metabolism processes is Reactive Oxygen Species (ROS).  The ROS group always contains Oxygen or Per Oxides and is highly unstable. ROS can also be generated as a result of ionizing radiation such as UV radiation.</p>
<p>Free radicals are constantly created in the body during normal metabolism, ROS play a major role in inter cell communication that govern basic cell activities and coordinates the cell’s reactions to its micro environment, for example, initiating the tissue healing process in cases of injury. They are also deployed by the immune system as a way to attack and kill harmful bacteria such as Acne bacteria, the reactive oxygen &#8211; O<sub>2</sub><sup>- </sup>molecule is highly toxic and is actually deployed to destroy these bacteria and it is also an important component of “cell suicide” needed to remove cancerous cell, damaged cells or cells whose life span had reached its end.</p>
<p>The body deals with the free radicals, more specifically ROS, via specific enzymes that break them down or neutralize them or through Antioxidants such as vitamins C and E, Uric acid and more.  Antioxidants prevent oxidative reactions, often by scavenging ROS before they can damage cells.</p>
<p>Normally, the body can handle ROS, but if antioxidants are unavailable, or if the ROS production becomes excessive, damage can occur which is labeled “Oxidative Stress”. Of particular importance is that ROS damage accumulates with age. This can be as a result of increased ROS production combined with a decrease in cellular Anti Oxidant activity.</p>
<p>The market is flooded with antioxidants for anti aging in all forms, from specific juices, extracts and pills. It is a heavily used term when it comes to food advertising and of course in anti aging cosmetics.</p>
<p>But are antioxidents always good for you? Analysis of data from many studies demonstrated that use of large quantities of anti oxidants can actually cause harm and shorten life span. It can also interfere with cancer treatment and prevent the recovery process after strenuous exercise as the ROS actually remove damaged and cancerous cells.</p>
<p>Free Radicals do cause acceleration of skin aging. Exposure to UV, stress, smoking and alcohol can increase ROS levels in the skin. The free radicals will altar the structure of our proteins, therefore damaging the collagen and weakening cellular structure. Unfortunately research has not demonstrated that ingestion or topical use of Antioxidants can prevent or eliminate wrinkles or other effects of aging skin. Merely taking antioxidant supplements will not correct the loss of skin elasticity or make the facial skin look younger.</p>
<p>So what can be done to reduce the affect of free radicals on the aging skin?</p>
<p>First, avoid UV damage by avoiding exposure to sunlight during dangerous hours in addition always apply a sunscreen when out in daylight.  Avoid smoking and large quantities of alcohol. Consume a diet with abundant quantities of vegetables and some fruit (too much sugar is also not beneficial to skin), and find ways to reduce your stress levels.</p>
<p>One way of repairing the damage to the skin and to induce collagen regeneration is via treatments using the <a href="http://www.pollogen.com/Tripollar-RF-Technology/Tripollar-Overview.html">TriPollar</a> RF technology. This treatment will stimulate the fibroblast to generate new collagen fibers and to produce a thicker and denser dermal layer therefore reducing the visible signs of aging skin caused by the aging process and by exposure to free radicals.</p>
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